Science Behind the Production and Usage of an NMN Supplement

Many scientific investigations have shown that NMN can reduce ageing and work as a longevity element. As a result, NMN supplements are now widely popular and becoming more available in the markets. But every supplement is different.

When buying, ensure that your NMN supplement is made in a facility like www.eternumlabs.com.au that follows GMP (Good Manufacturing Practices) and updated ISO standards.

Why Should You Refrain From Low-Quality NMN Supplements?

Given the high cost of manufacturing NMN and high demand, some manufacturers adulterate their goods to cut expenses and increase profits.

Unscrupulous merchants offer low-purity NMN supplements or even pills that do not even contain NMN. These companies advertise their products as “high-purity”, yet they are actually low pills with less than 80% purity. Customers have no idea what the remaining 20% includes. It could simply be fillers like flour or harmful compounds formed as a by-product of the NMN manufacturing process.

Even “NMN supplements” contain only nicotinamide, a B vitamin that appears similar to NMN but has completely different effects on the body. So, here are some of the points to consider when scouting the market for an anti-ageing formula that works for you.

Foods with a High Amount of NMN

Avocado, broccoli, cabbage, cucumbers, and edamame are just a few examples of foods that contain NMN naturally. While these foods are a good source of nutrients, some people prefer to take dietary supplements to boost their intake beyond what they can get from their meals. To buy the best quality and safe lab-tested NMN supplement, visit https://eternumlabs.com.au/.

How is NMN Produced?

The vitamins B found in the body are used to make NMN. Nicotinamide phosphoribosyltransferase is the enzyme that produces NAMPT. The latter binds nicotinamide, a kind of vitamin B3, to the sugar-phosphate 5′-phosphoribosyl-1-pyrophosphate.

Since NAMPT is the rate-limiting enzyme in the generation of NAD+, lower enzyme levels result in reduced NMN production and consequently lower NAD+ levels. This also indicates that with more NMN, the rate of the NAD+ production can be boosted, helping to make up for the deficiency.

The addition of a phosphate group to NR can also result in the formation of NMN. It was previously considered that NMN could not enter the cell without first becoming NR. But the Slc12a8 gene encodes a unique NMN transporter that permits the molecule to enter cells without first being converted to NR.

What are NMN and NAD+, and What is Their Function?

Nicotinamide mononucleotide or NMN is a naturally occurring chemical found in all living things. It is a ribonucleotide, a fundamental structural unit of nucleic acid RNA (at the molecular level). It has a nicotinamide group, a ribose group, and a phosphate group in its natural state. It is a precursor molecule for the important chemical nicotinamide adenine dinucleotide (NAD+) and a method for increasing NAD+ levels in the cell.

NAD+ is a vital coenzyme found in all living cells and is required for survival. It’s a dinucleotide, which means it is made up of two nucleotides that their phosphate groups link. The adenine base is present in one nucleotide, whereas nicotinamide is present in the other. NAD+ is one of the body’s most adaptable chemicals, and it is a hot topic in ageing research.

Aside from water, NAD+ is the most prevalent in the body, and without it, life itself will perish. Several proteins in your body, including the sirtuins that help repair damaged DNA, can utilise NAD+.

It’s also vital for mitochondria or the cell’s powerhouses and produces the chemical energy that human bodies require.

NAD+ as a Coenzyme

NAD+ is particularly important in metabolic activities, including glycolysis, the TCA cycle, and the electron transport chain, which takes place in your mitochondria. It is how you get cellular energy.

NAD+ binds to enzymes and transfers electrons between molecules in its capacity as a ligand. NAD+ functions through a cellular mechanism comparable to recharging a battery by transferring electrons from one molecule to the next.

Electrons are the atomic basis for cellular energy. When electrons are used to provide energy, a battery gets drained. Without a recharge, those electrons will not be able to return to their starting place. NAD+ serves as a booster in cells and can reduce or boost enzyme activity, gene expression, and cell signalling in this way.

Prevention of DNA Damage

As organisms age, environmental factors such as radiation, pollution, and inaccuracy in DNA replication cause DNA damage. The accumulation of DNA damage, according to contemporary ageing theories, is the primary cause of ageing.

The “molecular machinery” to repair the damage is found in almost all cells. NAD+ and energy molecules are consumed by this mechanism. As a result, severe DNA damage might deplete crucial cellular resources.

NAD+ is required for the action of one essential DNA repair protein, PARP (Poly-ADP-ribose polymerase). The amount of NAD+ in the body decreases when people age, resulting in DNA damage accumulating. It causes a rise in PARP and a drop in NAD+ concentration. Any additional DNA damage in the mitochondria exacerbates this depletion.

NMN Risks and Benefits

In animal investigations, researchers attempt to understand how this molecule works in the human body with the promising therapeutic capabilities NMN exhibits. A recent clinical trial in Japan has shown that the molecule in the utilised dose is safe and well-tolerated. More investigations and human trials are being conducted.

Although NMN elevated bilirubin levels in the blood in one particular case of Japanese males published in November 2019, these levels remained normal. Future research should examine long-term safety and efficacy.

NMN has had no recognised negative effects till now. It’s a fascinating and adaptable chemical that we still have a lot to learn from and about before any extensive use.

Conclusion

Except for the safety research in Japan, NMN is still in its infancy, and there is currently no human data. NMN is still being sold as a dietary supplement and an NAD+ booster despite this. Despite the absence of human data, it has become popular among those who believe it can be used as an anti-ageing supplement. When buying this supplement, though, look carefully at the label to check its ingredients.